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CAS No. 109693 | Sigma-Aldrich
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Sigma-Aldrich is a leading Life Science and High Technology company. Our products are used worldwide to enable science that improves the quality of life. Sigma-Aldrich: Analytical, Biology, Chemistry & Materials Science products and services. | Sigma-Aldrich
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2021/1/6 · In vitro In the absence of FKBP12, Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM. Temsirolimus treatment at nanomolar concentrations (10 nM to 5 μM) displays a modest and selective antiproliferative activity via FKBP12-dependent mechanism, but can completely inhibit the proliferation of a broad panel of tumor
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